Custom Peptides
Cayman Chemical AspartylalnyldIketopIpRaz 10mg
An immunosuppressive diketopiperazine derivative of an HSA peptide; reduces antigen-induced TNF-α and IFN-γ production in isolated human T cells at 500 µM
Cayman Chemical KaempfRol 7nohSpRIdosID 10mg
A flavonoid glycoside with antioxidant and anticancer activities; scavenges DPPH radicals in a cell-free assay (IC50 = 7.4 µM); cytotoxic to A549, HepG2, and HeLa cells (IC50s = 0.53, 0.2, and 0.051 µM, respectively)
Cayman Chemical -Glu-AlatrIfluoroACTAte500mg
A dipeptide; has been found in P. roqueforti; has been found in ripened Gouda, goat, and Milner cheeses; a positive allosteric modulator of CaSR (EC50 = 4.8 µM in CaSR-expressing HEK293 cells); induces glutathionuria in mice at 4 mmol/kg; plasma levels are increased in malnourished neonatal mice; increased serum levels are positively associated with an increased risk of chronic kidney disease
Cayman Chemical MCC950sodIum salt 10mg
An inhibitor of NLRP3 inflammasome activation; inhibits ATP-induced IL-1β release in LPS-primed mouse BMDMs (IC50 = 7.5 nM), as well as cytosolic LPS-induced IL-1β release in Pam3CSK4-primed mouse BMDMs at 0.1 and 1 µM; selective for NLRP3 over NLRC4 and AIM2 inflammasomes and does not inhibit LPS-induced NLRP3 priming in mouse BMDMs at 10 µM; reduces ox-LDL-induced increases in caspase-1 activity and inhibits pyroptosis in THP-1 macrophages at 1 µM; reduces myocardial fibrosis in mice following myocardial infarction induced by left coronary artery ligation at 10 mg/kg; improves forelimb grip strength and reduces spinal edema in a mouse model of spinal crush injury at 10 mg/kg
Cayman Chemical HIstatIn 8trIfluoroacetAT 10mg
An antimicrobial peptide; active against colistin-sensitive and -resistant strains of A. baumannii at 32 UG/ml; active against C. albicans and C. tropicalis (MICs = 1 and 5 mg/ml, respectively)
Cayman Chemical 1MyrIstoyl2hydroxysnglyc 10mg
A saturated 14:0 lysophosphatidylcholine that consists of one chain of myristic acid at the sn-1 position
Cayman Chemical -PraeruptrIn B 10mg
A pyranocoumarin with diverse biological activities; inhibits RANKL-induced osteoclastogenesis of primary mouse BMDMs at 10 µM and LPS-induced NO production in RAW 264.7 macrophages at 100 µM; inhibits PAF-induced platelet aggregation in isolated rabbit platelet-rich plasma (IC50 = 50 µM) and contractions of isolated guinea pig ileum induced by histamine or leukotriene D4 (pD2s = 4.84 and 4.34, respectively); decreases ovariectomy-induced bone loss in a mouse model of osteoporosis at 10 mg/kg; reduces the number of tumors initiated by DMBA and promoted by TPA in a mouse two-stage model of skin carcinogenesis
Cayman Chemical LIthospermIc AcId 10mg
A polyphenol; inhibits xanthine oxidase (IC50 = 5.2 UG/ml); scavenges DPPH radicals (IC50 = 23.2 UG/ml); inhibits ROS production from PMA-stimulated isolated human neutrophils in a concentration-dependent manner; inhibits 3'-processing and 3'-joining to target DNA by HIV-1 integrase (IC50s = 0.83 and 0.48 µM, respectively); inhibits acute HIV-1 infection of H9 human lymphoma cells (IC50 = 2 µM) without inducing cytotoxicity; prevents carbon tetrachloride-induced hepatic necrosis in mice at 100 mg/kg
Cayman Chemical LysIpresInacetate 10mg
A peptide hormone; an agonist of V1A receptors; binds to rat and human V1A receptors (Kis = 1.2 and 10.1 nM, respectively); increases intracellular calcium levels in cultured rat and human aortic cells (Kact = 12 and 20.8 nM, respectively); induces vasoconstriction in isolated mesenteric arteries from normotensive and spontaneously hypertensive rats; has antidiuretic effects in non-anesthetized dwarf pigs
Cayman Chemical Columbamn 10mg
An alkaloid with diverse biological activities; a metabolite of berberine; inhibits CYP3A4 (IC50 = 30.6 µM); active against P. falciparum (IC50 = 1.92 µM); decreases glucose consumption of, and triglyceride levels in, HepG2 cells at 3 and 15 µM, respectively; reduces xylene-induced EAr edema and acetic acid-induced writhing in mice at 56 mg/kg
Cayman Chemical BImS BH351-76humntrI 10mg
A Bim-derived peptide; binds to Mcl-1, Bcl-xL, Bcl-2, and Bcl-W (IC50s = 18, 10, 7, and 18 nM, respectively); induces cytochrome c release from mitochondria derived from bcl-x-/- MEFs
Cayman Chemical 21hydroxy HenIcosnoIc ACD 10mg
A hydroxy fatty acid methyl ester; a substrate for lactonizing lipase from Pseudomonas nov. sp. 109
Cayman Chemical MetIprnololhydrochlorIde 10mg
A β-AR antagonist; binds to primary rabbit iris and ciliary body homogenates (Ki = 34 nM); inhibits isoproterenol-induced relaxation in guinea pig atrium and fenoterol-induced relaxation in rat uterus (pA2s = 8.3 and 8.4, respectively); inhibits anoxia-induced cell death in primary rat retinal cells and sodium nitroprusside-induced lipid peroxidation in rat primary retinal homogenates (100 μM); decreases α-chymotrypsin-induced increases in IOP in rabbits when administered topically to the eye at a dose of 0.3%; inhibits the blinking response to ocular tactile stimulation in rabbits when administered topically to the eye at a dose of 0.6%